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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

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The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

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‘White Lotus’ villain Jon Gries reveals the true crimes that inspired his twisty take on Greg/Gary
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When Season 3 of “The White Lotus” premiered last month, the shock was palpable when returning character Belinda recognized a familiar face at the resort in Thailand: Greg Hunt, the wily suitor of the late Tanya McQuoid.

As the season has unfolded, Greg (played by Jon Gries) has emerged as an antagonist, particularly after Belinda dove into the investigation surrounding Tanya’s death and learned that Greg, who now goes by Gary, evaded questioning by authorities.

On a show famous for reinventing itself, the same has been asked of the actor, who says that playing the ever-shifting character has been a welcome challenge and, like “White Lotus” itself, full of twists.

“In the beginning, I totally played him for a guy who was, you know, on his last legs,” Gries said in a recent interview with CNN, referencing Greg’s very apparent ill health in the first season of “White Lotus,” which premiered to rave reviews in summer 2021. He added: “When you play a character, you want to find his empathetic side, and you want to understand where they came from, and what got them to where they are.”

But when he was contacted by creator Mike White about appearing in Season 2, Gries realized he would have to adjust his framing of Greg, despite having previously imagined a “comprehensive history” for him on his own.

“(White) said, ‘I’m writing it right now, and I’m writing you, and I just need to know here and now: If you’re in, I’ll continue writing. If not, I’ll stop,’” Gries recalled.

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Come Season 3, Gries had to rewrite Greg’s backstory again, this time drawing from some unlikely sources for inspiration, like HBO docuseries “The Jinx,” about late convicted killer Robert Durst, and the case involving the man who came to be known as the Tinder Swindler.

Gries said he was struck by Durst’s “kind of seemingly even keel personality,” which served as a model for where Greg was headed, someone “who doesn’t really show a great deal of emotion, doesn’t seem to get too angry, just gets a little bit irritated and is dangerous.”

“There’s a bridled rage underneath. And those kind of people I find – at least with respect to Gary, Greg, Gary – fascinating,” he said.

And yet, while searching for an empathetic way back to portraying his character, Gries kept wondering if there was anything still redeeming about Greg.
An important “wake up moment” came during a decisive conversation he had with White just before filming in Thailand, in which the show’s creator said of Greg, in no uncertain terms: “He’s a psychopath.”

“And that was it. It was like, ‘back to the drawing board.’ And it really did help me,” Gries said.

The penultimate episode of the series will air on Sunday, an evening that thanks to “Lotus” and other shows has again become a night of appointment viewing amid a general move away from binge watching. Gries said he appreciates the shift.

“We’re a society that in a weird way doesn’t understand the beauty of waiting. The beauty of the space between the notes,” he shared. “If I binged (‘White Lotus’) I’d feel like I just ate too many chocolates. It just wouldn’t be the same. You need to process this.”

“The White Lotus” airs Sundays at 9 p.m. EDT on HBO, with the episode available to stream on Max. HBO and Max, like CNN, are owned by the same parent company, Warner Bros. Discovery.

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The voice of ‘White Lotus’ star Walton Goggins is the lullaby we didn’t know we needed
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While his “White Lotus” character Rick has been the source of some stress this season, Walton Goggins is here to soothe us into a state of dreamy sleep to make up for it.

The actor has partnered with relaxation and meditation app Calm for one of their famed Sleep Stories, lending his smoky voice to a fable titled “The Yard Sale.”

Goggins announced the Sleep Story on his verified Instagram on Tuesday, writing, “A friend once said to me the first question you ask someone shouldn’t be, ‘How are you?’ but rather, ‘How did you sleep last night?’ I agree.”

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In the caption, the actor also wrote that he “wanted to create a Sleep Story that feels dreamlike, helping people slow their minds down by wandering through a yard sale (which happens to be one of my favorite things to do), uncovering hidden treasures.”

“It’s the Walton Goggins version of counting sheep. I hope you enjoy,” he added.

Other celebrities who have read bedtime stories in the hopes of putting audiences to sleep include Dolly Parton and the late Jimmy Stewart, whose voice was featured in a Calm Christmas Sleep Story in 2023 thanks to generative AI technology.

Goggins currently stars on “The White Lotus,” where his character is often the most stressed out and tortured of the ensemble, at one point setting a slew of snakes free.

A tiny rainforest country is growing into a petrostate. A US oil company could reap the biggest rewards
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Guyana’s destiny changed in 2015. US fossil fuel giant Exxon discovered nearly 11 billion barrels of oil in the deep water off the coast of this tiny, rainforested country.

It was one of the most spectacular oil discoveries of recent decades. By 2019, Exxon and its partners, US oil company Hess and China-headquartered CNOOC, had started producing the fossil fuel.? They now pump around 650,000 barrels of oil a day, with plans to more than double this to 1.3 million by 2027.

Guyana now has the world’s highest expected oil production growth through 2035.

This country — sandwiched between Brazil, Venezuela and Suriname — has been hailed as a climate champion for the lush, well-preserved forests that carpet nearly 90% of its land. It is on the path to becoming a petrostate at the same time as the impacts of the fossil fuel-driven climate crisis escalate.

While the government says environmental protection and an oil industry can go hand-in-hand, and low-income countries must be allowed to exploit their own resources, critics say it’s a dangerous path in a warming world, and the benefits may ultimately skew toward Exxon — not Guyana.
Since Exxon’s transformative discovery, Guyana’s government has tightly embraced oil as a route to prosperity. In December 2019, then-President David Granger said in a speech, “petroleum resources will be utilized to provide the good life for all … Every Guyanese will benefit.”

It’s a narrative that has continued under current President Mohamed Irfaan Ali, who says new oil wealth will allow Guyana to develop better infrastructure, healthcare and climate adaptation.

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“You have a government that is reckless about what is going to happen to Guyana,” said Melinda Janki, an international lawyer in Guyana who is handling several lawsuits against Exxon. It’s pursuing “a supposed course of development that is actually backward and destructive,” she told CNN.
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And while plenty of Guyanese people welcome the new oil industry, some say Guyana’s startling economic statistics do not reflect a real-world prosperity for ordinary people, many of whom are struggling with the higher prices accompanying the oil boom. Inflation rose 6.6% in 2023, with prices of some foods shooting up much more rapidly.

“Since the oil extraction began in Guyana, we have noticed that our cost of living has gone sky high,” said Wintress White, of Red Thread, a non-profit that focuses on improving living conditions for Guyanese women. “The money is not trickling down to the masses,” she told CNN.

CNN contacted President Ali, the Ministry of Natural Resources and the Ministry of Finance for comment but received no response.
Guyana, a former Dutch then British colony which gained independence in 1966, is one of only a handful of countries that is a “carbon sink,” meaning it stores more planet-heating pollution than it produces. This is due to its vast rainforest; trees remove carbon dioxide from the atmosphere as they grow.

The country has protected its biodiversity where others have destroyed theirs, President Ali said in a BBC interview last year. In 2009, the country signed an agreement with Norway, which promised Guyana more than $250 million to preserve its 18.5 million hectares, or nearly 46 million acres, of forests.

Ali insists the country can balance climate leadership and fossil fuel exploitation. The new oil wealth will allow Guayana to develop, including building climate adaptations such as sea walls, he has said. He has also pointed to the continued failures of wealthy countries, already grown rich on their own fossil fuels, to help poorer countries with climate finance.

But there are concerns Guyana could fall victim to the “resource curse,” in which vast, new wealth ?can actually make life worse for those who live there.

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Critics say this power imbalance is clear in the 2016 contract Guyana signed with Exxon. Under the agreement, Exxon keeps 75% of everything it makes from its oil operations in Guyana, with the remaining 25% shared equally between the company and the government, which also takes a 2% royalty.
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“It was a bad deal,” Ali said in the BBC interview, but he has rejected the idea of unilaterally changing the agreement, which was signed by the previous government. He says the next contract with Exxon will be on different terms.

An Exxon spokesperson said the contract is “globally competitive for countries at a similar stage of exploration” and said Guyana is averaging $1 billion a year in “oil profits.”

Exxon has also faced a number of lawsuits over its potential environmental impact, many filed by Melinda Janki, a Guyanese international lawyer, who drafted the country’s Environmental Protection Act back in the 1990s.

A big victory for Guyana’s people and environment came in 2023, when the court ruled Exxon should have unlimited liability for the costs of any oil spill. Exxon has since appealed the ruling and has posted a $2 billion guarantee while it awaits the appeal outcome.
Exxon said this commitment supplements “its robust balance sheets … and the insurance policies they already had in place.” Janki says this isn’t enough. Offshore oil spills can be extremely expensive to deal with, the 2010 Deepwater Horizon spill cost nearly $70 billion to clean up.

The push and pull between those who say oil offers Guyana a brighter future and those who fear the industry’s impact will continue.

Exxon said it’s had a positive impact on the country, including employing more than 6,200 people, investing more than $2 billion with local Guyanese businesses since 2015 and spending more than $43 million on community projects.

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